| Sara Bareilles |
| Sara Evans |
| Sarah Brightman |
| Sarah Harmer |
| Sarah McLachlan |
| Savage Garden |
| Savoy Brown |
| Saxon |
| Scandal |
| Scarface |
| Schoolly D |
| Scorpions |
| Scott Larson |
| Scott McKenzie |
| Scott Stapp |
| Screaming Trees |
| Scritti Politti |
| Seal |
| Seals and Crofts |
| Sean Paul |
| Sebadoh |
| Sebastian Bach |
| Seduction |
| Seether |
| Semisonic |
| Sérgio Mendes |
| Seven Mary Three |
| Sex Pistols |
| Shabba Ranks |
| Shadows of Knight |
| Shaggy |
| Shai |
| Shakespears Sister |
| Shakin’ Stevens |
| Shalamar |
| Shania Twain |
| Shanice |
| Shannon |
| Shawn Colvin |
| Shawn Mullins |
| Shayal, Ginuwine and Anu Shukla |
| Sheena Easton |
| Sheila E. |
| Sheriff |
| Sheryl Crow |
| Shinedown |
| SHINEHEAD |
| Shirley Bassey |
| Shocking Blue |
| Shorty Long |
| Shriekback |
| Shuggie Otis |
| Silk |
| Silver |
| Silver Convention |
| Silverstein |
| Silversun Pickups |
| Simon & Garfunkel |
| Simon Kirke |
| Simple Minds |
| Simple Plan |
| Simply Red |
| Sinéad O’Connor |
| Siouxsie and the Banshees |
| Sir Mix-a-Lot |
| Sista Sensi |
| Sister Hazel |
| Sister Janet Mead |
| Sister Sledge |
| Sisters of Mercy |
| Sixpence None the Richer |
| Sixx:A.M. |
| Skee-Lo |
| Skepta |
| Skid Row |
| Skillet |
| Skunk Anansie |
| Skylark |
| Slade |
| Slash |
| Slaughter |
| Slayer |
| Sleater-Kinney |
| Slick Rick |
| Slim Harpo |
| Slint |
| Slipknot |
| Slowdive |
| Sly Fox |
| Smash Mouth |
| Smith |
| Smokey Robinson |
| Snap! |
| Sniffin’ the Tears |
| Snoop Dogg |
| Snow |
| Snow Patrol |
| Social Distortion |
| Sodom |
| Sofi Tukker |
| Soft Cell |
| Soft Machine |
| Soilwork |
| Somethin’ for the People featuring Trina & Tamara |
| Son Volt |
| Sonic Boom/Peter Kembler |
| Sonic Youth |
| Sophie B. Hawkins |
| Sophie Ellis-Bextor |
| Soul Asylum |
| Soul for Real |
| Soul II Soul |
| Soul Station (Paul Stanley) |
| Soulfly |
| Soundgarden |
| Southside Johnny |
| Spacehog |
| Spandau Ballet |
| Sparklehorse |
| Sparks |
| Spice Girls |
| Spin Doctors |
| Spiral Starecase |
| Spiritualized |
| Spizz Energi |
| Sponge |
| Spoons |
| Squarepusher |
| Squeeze |
| Squirrel Nut Zippers |
| Stabbing Westward |
| Stacey Q |
| Staind |
| Starbuck |
| Starjets |
| Starland Vocal Band |
| Starpoint |
| Starship |
| Static-X |
| Status Quo |
| Stealers Wheel |
| Steel Panther |
| Steel Pulse |
| Steeleye Span |
| Steely Dan |
| Stephanie Mills |
| Stephen Bishop |
| Stephen Malkmus |
| Steppenwolf |